Mesoporous silica-based nanodevices (MSN) bearing a targeting molecule on the outer surface and an antineoplastic pro-drug linked within the pores by means of a pH-sensitive bond, as vehicles for targeting and release of biologically active molecules, are developed to be employed in targeted therapy. Suitable nanostructuring of matter better than with polymers because of nanoarchitecture and surface reactivity. Their pH-sensitive bond provides pro-drug (a biologically inactive form) delivery through the bloodstream (pH 7.4), until nanosystems reach the target tissue (pH 4-5), where they release the active form of the drug.
Our products technology is based on science of materials, providing nanostructured particles that can be administered intravenously, and, through the bloodstream they can reach cancer cells, interact with them through a biological process and release a drug within. This leads to reduction of therapeutical doses, with a consequent therapeutic efficacy improvement and without toxic and side effects. NanoSiliCal Devices designs and produces the following products.
MSN carriers of a pro-drug and a targeting function
Fluorescent MSNs for imaging diagnostics
Mesoporous silicas micro- or nano-systems linked with a highly specific ligand and a fluorescent marker that allows the visualization of target cells.
MSNs linked to plasmidic DNA for gene therapy
Mesoporous silicas micro- or nanosystems coupled to a specific functional group and with pores able to include plasmidic DNA, coding for proteins that have to be expressed in cellular systems (e.g. in basic experimental research), or in a specific organism, in case of deficits associated to a particular disease (gene therapy).
MSN for drug targeting with avidin-biotin system
Mesoporous silicas micro- or nanosystems anchored, through an avidin group, to a biotin-linked specific molecule (such as a monoclonal antibody, directed against a tumor marker). The system, conjugated to a drug with pH sensitive release control, is able to promote a ligand-mediated internalization into cells, causing their death.